Stem Cells Homeostasis and Aging

Friday, November 10, 2023

8:00 AM – 9:30 AM ET

Location: Room 118

Chair(s)

Emmanuelle Passegue, PhD (she/her/hers)

Alumni Professor of Genetics and Development; Director of the Columbia Stem Cell Initiative
Columbia University
New York City, New York, United States

Individual Symposium Abstract First Author(s)

Emmanuelle Passegue, PhD (she/her/hers)

Alumni Professor of Genetics and Development; Director of the Columbia Stem Cell Initiative
Columbia University
New York City, New York, United States
Michael Bonaguidi, PHD (he/him/his)

Assistant Professor
Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research at USC
University of Southern California
Los Angeles, California, United States
David Castillo-Azofeifa, PhD (he/him/his)

Principal Scientist
Genentech, Inc.
South San Francisco, California, United States

Adult (tissue) stem cells support tissue homeostasis and repair throughout the life of an individual. Numerous changes occur with age that result in altered stem cell behavior and reduced tissue maintenance and regeneration. Changes can be cell autonomous including changes in cell cycle progression, decreased bioenergetic efficiency, increased DNA damage, and epigenetic alterations. In addition, poorly understood changes to the local and systemic environments occur that result in decreased stem cell activity or alterations in commitment or differentiation potential. This symposium will cover the impact of aging on multiple adult stem cell systems, including hematopoietic stem cells (HSCs), intestinal stem cells (ISCs), and neural stem cells.

Learning Objectives:

After attending this session, participants will be able to understand how aging can lead to changes in stem cell behavior, ranging from loss of self-renewal capacity to changes in potency.
After attending this session, participants will be able to compare and contrast how aging impacts adult stem cells in the brain, hematopoietic system, and intestine.

Presentations:

8:00 AM – 9:30 AM ET

Autophagy Counters Inflammation-Driven Glycolytic Impairment in Aging HSCs
Individual Symposium Abstract First Author: Emmanuelle Passegue, PhD (she/her/hers) – Columbia University
8:00 AM – 9:30 AM ET

Response of Neural Stem Cells to Developmental, Homeostatic and Aging cues
Individual Symposium Abstract First Author: Michael Bonaguidi, PHD (he/him/his) – University of Southern California
8:00 AM – 9:30 AM ET

Chronic IFNγ-Driven Inflammation Impairs Intestinal Tolerance and Regeneration in Aging
Individual Symposium Abstract First Author: David Castillo-Azofeifa, PhD (he/him/his) – Genentech, Inc.