Principal Investigator
NIA
Baltimore, Maryland, United States
After finishing his undergraduate degree in physics in Morocco, Mustapha Bouhrara moved to France where he obtained a professional Master's degree in biomedical engineering from Sophia Antipolis University of Nice in 2007, a research Master's degree in morphological, metabolic, functional, and molecular imaging from Claude Bernard University of Lyon in 2008, and his Ph.D. in biophysics and magnetic resonance imaging from Blaise Pascal University of Clermont-Ferrand in 2012. He was a Postdoctoral Visiting Fellow, Research Fellow, and Staff Scientist at the Laboratory of Clinical Investigation of the National Institute on Aging (NIA) from 2012 until 2020. In 2020, Dr. Bouhrara obtained the prestigious Stadtman Investigator Award. He is currently serving as a Principal Investigator and the Chief of the Magnetic Resonance Physics of Aging and Dementia (MRPAD) Unit at the NIA of the National Institutes of Health (NIH). Dr. Bouhrara has received various awards, including the NIA Director's Award in 2017 and 2019, and the NIH Award of Merit in 2018 for his work on myelin and cerebral blood flow quantifications applied to aging and dementia.
Mustapha's researcher focuses on developping accurate biomarkers that will assist with differential diagnosis, characterize the rate of disease progression, and facilitate development of therapeutics. This research program incorporates three major distinct, but complementary, components. The first component is developing novel magnetic resonance (MR) techniques for the quantification of fundamental determinants of the CNS, including myelin content, axonal densities, neuroinflammation, iron content, sodium content, cerebral blood flow. The second component involves studying the effects of reversible and nonreversible risk factors on these imaging biomarkers of CNS's microstructure, composition and function. The third component is studying the impact of changes in these imaging biomarkers on functional, behavioral and cognitive impairments, in addition to combining them with liquid biopsy biomarkers to elucidate the mechanisms underlying cerebral aging.
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Emerging MR Imaging and Spectroscopy Applications for Aging Research in Model Organisms
Friday, November 10, 2023
4:30 PM – 6:00 PM ET