Professor of Physiology
Perelman School of Medicine at the University of Pennsylvania
Philadelphia, Pennsylvania, United States
Joseph A. Baur, PhD
Professor
Institute for Diabetes, Obesity, and Metabolism, and Department of Physiology
Perelman School of Medicine, University of Pennsylvania
The Baur lab is interested in the basic mechanisms that lead to aging, which is a major risk factor for obesity, diabetes, and related complications. Although the causes of aging are not known, it can be delayed experimentally in rodents by decreasing energy intake in the absence of malnutrition (caloric restriction, CR), and much of our work is centered on elucidating the mechanism(s) by which CR improves health and ameliorates age-related diseases. One major focus of the lab is on changes in nicotinamide adenine dinucleotide (NAD) metabolism in aging, obesity, and cardiovascular disease. Intramuscular NAD levels fall with age and are increased by CR, and correlated with muscle performance. NAD levels are low in failing hearts, and supplementation promotes functional improvements. We are also studying the regulation of mitochondrial NAD stores, which are compartmentalized and mediated by the activity of SLC25A51.
Disclosure information not submitted.
Thursday, November 9, 2023
12:00 PM – 1:30 PM ET
3 - NAD+ Metabolism in Mitochondria and Microbes
Thursday, November 9, 2023
12:00 PM – 1:30 PM ET