Senior Investigator
NIEHS
Research Triangle Park, North Carolina, United States
Dr. Xiaoling Li is currently a Senior Investigator at National Institute of Environmental Health Sciences (NIEHS). She received her Bachelor degree in Biochemistry from Peking University in China in 1994, her Master degree in Molecular Biology from Institute of Biophysics of Chinese Academy of Sciences in 1997, and her Ph.D. in Biological Chemistry from the Johns Hopkins School of Medicine in 2002. She joined NIEHS as a Principal Investigator in 2007 after her postdoctoral training at Massachusetts Institute of Technology. Dr. Li’s research seeks to understand how metabolism interacts with protein modification enzymes to mediate environmental regulation of cellular functions, and to further assess how dysregulation of this interplay contributes to pathogenesis of disease and aging. Specifically, her group focuses on a nutrient-sensing pathway consisting of NAD+, SIRT1, the most conserved mammalian NAD+-dependent protein deacetylase/deacylase, and protein acylations. Utilizing mice and cultured cells as model systems, they combine molecular, cellular, and genetic approaches to study the interplay of SIRT1, protein acylation, and the environment (e.g. diets/nutrients, microbes). Their current research areas include metabolic and epigenetic regulation of stem cells and cancer cells, diet-microbiota interaction in regulation of host NAD+ metabolism and related (patho)physiology, and diet-microbiota interaction in regulation of intestinal tissue homeostasis, inflammation, and tumorigenesis.
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Thursday, November 9, 2023
12:00 PM – 1:30 PM ET
2 - Host-Microbe Metabolic Interactions in Disease and Aging
Thursday, November 9, 2023
12:00 PM – 1:30 PM ET