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Symposium

Health Sciences

Mechanisms Underlying Sleep and Development of Chronic Conditions in Older Adults

Saturday, November 11, 2023
5:30 PM – 7:00 PM ET
Location: Room 122

Mounting evidence suggests poor sleep is associated with the development of chronic conditions. Numerous mechanisms for these links have been proposed, including inflammation, metabolic function, and brain structure. In this symposium, we will present five studies focused on links between poor sleep and subsequent development of chronic disease across adulthood. Specifically, we will examine this relationship at multiple levels from the cellular to the clinical level with the ultimate goal of identifying potential mechanisms and consequences of links between poor sleep and chronic conditions. Paper 1 will identify within-person patterns of various sleep experiences and link them to incident chronic conditions over a 10-year period. Paper 2 will examine associations between sleep parameters, measured via wrist actigraphy, and levels of adipokines, which are adipose-derived cytokines associated with development of metabolic disease. In Paper 3, we will shift our focus to examine the association between poor sleep and inflammatory biomarkers, specifically C-reactive protein, circulating and lipopolysaccharide-stimulated cytokines. Paper 4 will assess the impact of poor sleep health on fear of falling and actual falls. Paper 5 will focus on the effects of poor sleep and arousal with cognition and brain structure, specifically within a population of patients with chronic pain. As Discussant, Dr. Christina McCrae will integrate these findings and suggest directions for future research. In summary, our symposium will elucidate biological and psychological mechanisms linking poor sleep to manifestation of chronic disease. Better understanding of these mechanisms will inform the development of interventions to promote successful aging.

Learning Objectives:

  • Describe the importance of optimal sleep to reduce the risk of chronic disease
  • Characterize the potential mechanisms for the association between poor sleep and chronic disease
  • Identify interventions for poor sleep that may be particularly helpful in patients at risk for chronic disease in late life

Presentations:

  • 5:30 PM – 7:00 PM ET
    Sleep Tight, Stay Healthy? Multidimensional Sleep Health and Chronic Condition Development Over One Decade

    Individual Symposium Abstract First Author: Claire E. Smith, PhD (she/her/hers) – University of South Florida

  • 5:30 PM – 7:00 PM ET
    Associations of Actigraphic Sleep With Adipokines in Older Adults

    Individual Symposium Abstract First Author: Yiwei Yue, MD, MSPH (she/her/hers) – Johns Hopkins Bloomberg School of Public Health

  • 5:30 PM – 7:00 PM ET
    Gender Differences in the Association Between Sleep and Inflammatory Markers: Results From the Einstein Aging Study

    Individual Symposium Abstract First Author: Linying Ji, PhD (she/her/hers) – Montana State University

  • 5:30 PM – 7:00 PM ET
    Poor Sleep Health May Build the Onset of a Fear of Falling Among Community-Dwelling Older Adults

    Individual Symposium Abstract First Author: Tuo-Yu Chen, PhD – Taipei Medical University

  • 5:30 PM – 7:00 PM ET
    Interactive Role of Sleep and Arousal on Cognition and Brain Structure in Chronic Pain Patients

    Individual Symposium Abstract First Author: Ashley F. Curtis, PhD (she/her/hers) – University of South Florida